NAICS 621111
Physician Practices in San Mateo, CA
The 4 ZIP codes assigned to San Mateo contained 113 Medical Practice establishments in 2023, of which 17 employed 10 or more people.
- Establishments (2023)
- 113
- 4 ZIP codes
- 10 or more employees
- 17
- Practical financing floor
- Share of county
- 28%
- San Mateo County
- City population
- 103,337
- 2025 estimate
Figures cover the ZIP codes the U.S. Postal Service assigns to San Mateo (94401, 94402, 94403, 94404). ZIP areas are not municipal boundaries: they can extend beyond city limits and are shared between neighbouring places. This is a count of establishments in San Mateo's ZIP codes, not a count of businesses inside its city limits.
Establishments by size
Employee-count distribution. For most buyers the businesses worth pursuing sit in the 5 to 49 range: large enough to have a manager and real systems, small enough to be owner-operated.
| Employees | Establishments | Share | Distribution |
|---|---|---|---|
| 1-4 | 76 | 67.3% | |
| 5-9 | 14 | 12.4% | |
| 10-19 | 9 | 8.0% | |
| 20-49 | 8 | 7.1% |
How this market compares
San Mateo against every other city in California on the same measure. City figures cover the ZIP codes assigned to the place rather than its municipal boundary, so they are compared as a share of the businesses in those same ZIP codes rather than per resident. Cities with fewer than 500 businesses in total are left unranked.
About the same slice of the local business base as the industry holds statewide.
- Vs state share
- -8%
- Share of local businesses
- Rank by count
- #57
- of 373 cities
- Rank by share
- #136
- of 297 ranked
- Since 2020
- -3%
- Change in establishments
This compares how much of San Mateo’s business base is physician practices, against the California figure. Base: 4,307 establishments across all industries in the same ZIP codes, 2023. It does not measure revenue, profitability or whether a market is worth entering.
Business size mix
San Mateo tracks the California size distribution closely.
| Share of establishments | San Mateo | California | Difference |
|---|---|---|---|
| Under 5 employeesOwner-operated, often no management layer | 67.3% | 65.6% | +1.6% |
| 5 to 49 employeesThe range most individual buyers target | 27.4% | 27.4% | -0.0% |
| 10 or more employeesPractical floor for acquisition financing | 15.0% | 12.9% | +2.2% |
Nearest comparable markets
The closest places to San Mateo that also have Medical Practice establishments on record. Useful for spotting a gap next door, or realising the market you are looking at is already served from the town over.
| Market | Establishments | Vs state share |
|---|---|---|
| Belmont | 9 | -54% |
| Burlingame | 68 | +9% |
| San Carlos | 11 | -72% |
| Millbrae | 3 | -80% |
| Redwood City | 61 | -35% |
The wider San Mateo County market
Employment and payroll are reported at county level only, so the figures below describe the county San Mateo sits in.
- County establishments (2023)
- 405
- San Mateo County
- County employees
- 4,466
- Mid-March employment
- County annual payroll
- $610M
- All establishments
What acquirers look at
California’s corporate practice of medicine doctrine restricts lay ownership, so deals are structured as MSO arrangements. Not a first acquisition for an unlicensed buyer.
Other industries in San Mateo
Nearby cities
Sources
- U.S. Census Bureau, 2023 ZIP Code Business Patterns. Establishment counts and size distribution by ZIP code and NAICS, aggregated over the ZIP codes assigned to each city. Retrieved 2026-09-08.
- U.S. Census Bureau, 2023 County Business Patterns. Establishment counts, employment and annual payroll by NAICS. Retrieved 2026-09-08.
- U.S. Bureau of Labor Statistics, Quarterly Census of Employment and Wages (2026Q1). Quarterly establishment counts and employment for employers covered by unemployment insurance. Retrieved 2026-09-08.