South San Francisco, CA Business Index
South San Francisco is a city in San Mateo County with an estimated 64,941 residents as of 2025, down 1.5% since 2020. South San Francisco's business base is indexed below across 48 owner-operated industries.
- Population (2025)
- 64,941
- U.S. Census Bureau estimate
- Change since 2020
- -1.5%
- 2020–2025
- Land area
- 9.2 sq mi
- 2023 Census Gazetteer
- Density
- 7,056/sq mi
- Residents per square mile
Population trend
Annual resident population estimates, U.S. Census Bureau Population Estimates Program.
| Year | Population | Year over year |
|---|---|---|
| 2020 | 65,913 | n/a |
| 2021 | 63,853 | -3.13% |
| 2022 | 63,370 | -0.76% |
| 2023 | 63,726 | +0.56% |
| 2024 | 64,481 | +1.18% |
| 2025 | 64,941 | +0.71% |
South San Francisco holds 8.7% of San Mateo County’s 743,568 residents.
Industries in San Mateo County
South San Francisco businesses compete in the San Mateo County market. Establishment counts, employment and payroll below are reported at county level by the U.S. Census Bureau.
HVAC & PlumbingViewElectricalViewRoofingViewLandscapingViewPest ControlViewPool ServiceViewCommercial CleaningViewFlooringViewGlass & GlazingViewSeptic & WellViewAuto RepairViewAuto BodyViewCar WashViewTowingViewTruckingViewEquipment RentalViewDentalViewVeterinaryViewHome HealthViewPharmacyViewMedical PracticeViewOptometryViewAccountingViewInsurance AgencyViewIT & MSPViewStaffingViewEngineeringViewArchitectureViewLaw FirmViewSecurity ServicesViewPrintingViewSign ShopsViewMachine ShopsViewMetal FabricationViewPlasticsViewFood ManufacturingViewMillworkViewRestaurantsViewBakeriesViewLiquor StoresViewGyms & FitnessViewSalons & SpasViewLaundromatsViewDry CleaningViewFuneral HomesViewSelf StorageViewChildcareViewPet ServicesView
Nearby cities
Other indexed places in San Mateo County and the surrounding area.
Data last refreshed from source on 2026-09-08.
Sources
- U.S. Census Bureau, Population Estimates Program (Vintage 2025). Subcounty resident population estimates. Retrieved 2026-09-08.
- U.S. Census Bureau, 2023 Gazetteer Files. Land area and internal point coordinates. Retrieved 2026-09-08.
- U.S. Census Bureau, ANSI/FIPS Place-to-County Relationship File Retrieved 2026-09-08.